Rxivist logo

Mitochondria surveillance systems trigger innate immune responses to bacterial pathogens via AMPK pathway in C. elegans

By Shouyong Ju, Hanqiao Chen, Shaoying Wang, Jian Lin, Raffi V Aroian, Donghai Peng, Ming Sun

Posted 17 Sep 2020
bioRxiv DOI: 10.1101/2020.09.17.301036

Pathogen recognition and triggering pattern of host innate immune system is critical to understanding pathogen-host interaction. It is generally accepted that the microbial infection can be recognized by host via pattern-triggered immunity (PTI) or effector-triggered immunity (ETI) responses. Recently, non-PRR-mediated cellular surveillance systems have been reported as an important supplement strategy to PTI and ETI responses. However, the mechanism of how surveillance systems sense pathogens and trigger innate immune responses is largely unknown. In the present study, using Bacillus thuringiensis - Caenorhabditis elegans as a model, we found a new approach for surveillance systems to sense the pathogens through no-PPRs patterns. We reported C. elegans can monitor intracellular energy status through the mitochondrial surveillance system to triggered innate immune responses against pathogenic attack via AMP-activated protein kinase (AMPK). Consider that the mitochondria surveillance systems and AMPK are conserved components from worms to mammals, our study suggests that disrupting mitochondrial homeostasis to activate the immune system through AMPK-dependent pathways may widely existing in animals.

Download data

  • Downloaded 133 times
  • Download rankings, all-time:
    • Site-wide: 102,985 out of 117,931
    • In immunology: 2,784 out of 3,289
  • Year to date:
    • Site-wide: 63,896 out of 117,931
  • Since beginning of last month:
    • Site-wide: 41,488 out of 117,931

Altmetric data

Downloads over time

Distribution of downloads per paper, site-wide


Sign up for the Rxivist weekly newsletter! (Click here for more details.)