Genetic variation and gene expression across multiple tissues and developmental stages in a non-human primate
By
Anna J. Jasinska,
Ivette Zelaya,
Susan K Service,
Christine B Peterson,
Rita M. Cantor,
Oi-Wa Choi,
Joseph DeYoung,
Eleazar Eskin,
Lynn A. Fairbanks,
Scott Fears,
Allison E. Furterer,
Yu S. Huang,
Vasily Ramensky,
Christopher A. Schmitt,
Hannes Svardal,
Matthew J. Jorgensen,
Jay R. Kaplan,
Diego Villar,
Bronwen L. Aken,
Paul Flicek,
Rishi Nag,
Emily S Wong,
John Blangero,
Thomas D. Dyer,
Marina Bogomolov,
Yoav Benjamini,
George Weinstock,
Ken Dewar,
Chiara Sabatti,
Richard K Wilson,
J. David Jentsch,
Wesley Warren,
Giovanni Coppola,
Roger P. Woods,
Nelson B Freimer
Posted 09 Dec 2016
bioRxiv DOI: 10.1101/092874
(published DOI: 10.1038/ng.3959)
By analyzing multi-tissue gene expression and genome-wide genetic variation data in samples from a vervet monkey pedigree, we generated a transcriptome resource and produced the first catalogue of expression quantitative trait loci (eQTLs) in a non-human primate model. This catalogue contains more genome-wide significant eQTLs, per sample, than comparable human resources, and reveals sex and age-related expression patterns. Findings include a master regulatory locus that likely plays a role in immune function, and a locus regulating hippocampal long non-coding RNAs (lncRNAs) whose expression correlates with hippocampal volume. This resource will facilitate genetic investigation of quantitative traits, including brain and behavioral phenotypes relevant to neuropsychiatric disorders.
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