Rxivist logo

Schizophrenia, Schizoaffective, and Bipolar Disorders share common illness traits, intermediate phenotypes and a partially overlapping polygenic basis. We performed GWAS on deep phenotyping data, including structural MRI and DTI, clinical, and behavioral scales from 1,115 cases and controls. Significant associations were observed with two cerebrospinal fluid volumes: the temporal horn of left lateral ventricle was associated with NRXN1, and the volume of the cavum septum pellucidum was associated with LRP1B and RORA. Both volumes were associated with illness. Suggestive associations were observed with local gyrification indices, fractional anisotropy and age at onset. This is the first report of common genetic variants associated with these intermediate phenotypes.

Download data

  • Downloaded 661 times
  • Download rankings, all-time:
    • Site-wide: 37,732
    • In genetics: 1,793
  • Year to date:
    • Site-wide: 63,614
  • Since beginning of last month:
    • Site-wide: 109,713

Altmetric data


Downloads over time

Distribution of downloads per paper, site-wide


PanLingua

Sign up for the Rxivist weekly newsletter! (Click here for more details.)


News