An effective, safe and cost-effective cell-based chimeric vaccine against SARS-CoV2
Nicholas R. Lemoine,
Posted 20 Aug 2020
bioRxiv DOI: 10.1101/2020.08.19.258244
Posted 20 Aug 2020
More than one hundred vaccines against SARS-CoV-2 have been developed and some of them have entered clinical trials, but the latest results revealed that these vaccines still face great challenges. Here, we developed a novel cell-based gp96-Ig-secreting chimeric vaccine which is composed of two viral antigens, the RBD of spike protein, and a truncated nucleocapsid protein that could induce epitope-specific cytotoxic T lymphocytes but low antibody response. Syrian hamsters immunized with the cell-based vaccine produced high level of SARS-CoV-2 specific NAbs and specific T cell immunity which could eliminate RBD-truncated N-expressing cells, without the induction of antibody against N protein and other observed toxicity. This study provides a proof of concept for clinical testing of this safe, effective and cost-effective vaccine against SARS-CoV2 infection. ### Competing Interest Statement The authors have declared no competing interest.
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