Rxivist logo

The specific features of the developing T cell compartment of the neonatal lung are a determinant of respiratory syncytial virus immunopathogenesis

By Thomas Demoulins, Melanie Bruegger, Beatrice Zumhehr, Blandina Oliveira Esteves, Kemal Mehinagic, Amal Fahmi, Loic Borcard, Adriano Taddeo, Horst Posthaus, Charaf Benarafa, Nicolas Ruggli, Marco P Alves

Posted 14 Aug 2020
bioRxiv DOI: 10.1101/2020.08.14.250829

The human respiratory syncytial virus (RSV) is a major cause of severe lower respiratory tract infections in infants, possibly due to the specific features of the immature neonatal pulmonary immune system. Using the newborn lamb, a classical model of human lung development and a state-of-the-art model of RSV infection, we aimed to explore the role of cell-mediated immunity in RSV disease during early life. Remarkably, in healthy conditions, the developing T cell compartment of the neonatal lung showed major differences to that seen in the mature adult lung. The most striking observation being a high baseline frequency of bronchoalveolar IL-4-producing CD4 and CD8 T cells, which declined progressively over developmental age. RSV infection exacerbated this pro-type 2 environment in the bronchoalveolar space, rather than inducing a type 2 response per se. Moreover, regulatory T cell suppressive functions occurred very early to dampen this pro-type 2 environment, rather than shutting them down afterwards, while γδ T cells dropped and failed to produce IL-17. Importantly, RSV disease severity was related to the magnitude of those unconventional bronchoalveolar T cell responses. These findings provide novel insights in the mechanisms of RSV immunopathogenesis in early life, and constitute a major step for the understanding of RSV disease severity. ### Competing Interest Statement The authors have declared no competing interest.

Download data

  • Downloaded 158 times
  • Download rankings, all-time:
    • Site-wide: 105,787
    • In immunology: 2,903
  • Year to date:
    • Site-wide: 39,828
  • Since beginning of last month:
    • Site-wide: 89,548

Altmetric data

Downloads over time

Distribution of downloads per paper, site-wide


Sign up for the Rxivist weekly newsletter! (Click here for more details.)