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DNA methylation signatures of aggression and closely related constructs: A meta-analysis of epigenome-wide studies across the lifespan

By Jenny van Dongen, Fiona A. Hagenbeek, Matthew J. Suderman, Peter Roetman, Karen Sugden, Andreas G. Chiocchetti, Khadeeja Ismail, Rosa H. Mulder, Jonathan Hafferty, MJ Adams, Rosie M. Walker, Stewart W Morris, Jari Lahti, Leanne K Küpers, Georgia Escaramis, Silvia Alemany, MJ Bonder, Mandy Meijer, Hill F. Ip, Rick Jansen, Bart M. L. Baselmans, Priyanka Parmar, Estelle Lowry, Fabian Streit, Lea Sirignano, Tabea Send, Josef Frank, Juulia Jylhävä, Yunzhang Wang, Pashupati Prasad Mishra, Olivier F. Colins, David Corcoran, Richie Poulton, Jonathan Mill, Eilis Hannon, Louise Arseneault, Tellervo Korhonen, Eero Vuoksimaa, Janine Felix, Marian Bakermans-Kranenburg, Archie Campbell, Darina Czamara, Elisabeth Binder, Eva Corpeleijn, Juan Ramón Gonzalez, Regina Grazuleviciene, Kristine B. Gutzkow, Jorunn Evandt, Marina Vafeiadi, Marieke Klein, Dennis van der Meer, Lannie Ligthart, BIOS Consortium, Cornelis Kluft, Gareth E. Davies, Christian Hakulinen, Liisa Keltikangas-Järvinen, Barbara Franke, Christine M. Freitag, Kerstin Konrad, Amaia Hervas, Aranzazu Fernández-Rivas, Agnes Vetro, Olli T. Raitakari, Terho Lehtimäki, Robert Vermeiren, Timo Strandberg, Katri Räikkönen, Harold Snieder, Stephanie H. Witt, Michael Deuschle, Nancy L. Pedersen, Sara Hagg, Jordi Sunyer, Lude Franke, Jaakko Kaprio, Miina Ollikainen, Terrie E. Moffitt, Henning Tiemeier, Marinus H. van Ijzendoorn, Caroline L. Relton, Martine Vrijheid, Sylvain Sebert, Marjo-Riitta Jarvelin, Avshalom Caspi, Kathryn L. Evans, AM McIntosh, Meike Bartels, Dorret Boomsma

Posted 22 Jul 2020
bioRxiv DOI: 10.1101/2020.07.22.215939

DNA methylation profiles of aggressive behavior may capture lifetime cumulative effects of genetic, stochastic, and environmental influences associated with aggression. Here, we report the first large meta analysis of epigenome wide association studies (EWAS) of aggressive behavior (N 15,324 participants). ### Competing Interest Statement The following authors declare a conflict of interest: Barbara Franke received educational speaking fees from Medice. Andrew M. McIntosh has received research support from Eli Lilly, Janssen and The Sackler Trust and speaker fees from Illumina and Janssen. Christine M. Freitag has received funding by the DFG, BMBF, State of Hessen, and the EU. She receives royalties for books on ASD, ADHD, and MDD.

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