Rxivist logo

A single-cell transcriptome atlas of the aging human and macaque retina

By Wenyang Yi, Yufeng Lu, Suijuan Zhong, Mei Zhang, Le Sun, Hao Dong, Mengdi Wang, Min Wei, Haohuan Xie, Hongqiang Qu, Rongmei Peng, Jing Hong, Ziqin Yao, Yunyun Tong, Wei Wang, Qiang Ma, Zeyuan Liu, Yuqian Ma, Shouzhen Li, Chonghai Yin, Jianwei Liu, Chao Ma, Xiaoqun Wang, Qian Wu, Tian Xue

Posted 17 Jul 2020
bioRxiv DOI: 10.1101/2020.07.17.207977 (published DOI: 10.1093/nsr/nwaa179)

The human retina is a complex neural tissue that detects light and sends visual information to the brain. However, the molecular and cellular processes that underlie aging primate retina remain unclear. Here, we provide a comprehensive transcriptomic atlas based on 119,520 single cells of the foveal and peripheral retina of humans and macaques covering different ages. The molecular features of retinal cells differed between the two species, suggesting the distinct regional and species specializations of the human and macaque retinae. In addition, human retinal aging occurred in a region- and cell-type- specific manner. Aging of human retina exhibited a foveal to peripheral gradient. MYO9A − rods and a horizontal cell subtype were greatly reduced in aging retina, indicating their vulnerability to aging. Moreover, we generated a dataset showing the cell-type- and region- specific gene expression associated with 55 types of human retinal disease, which provides a foundation to understand the molecular and cellular mechanisms underlying human retinal diseases. Together, these datasets are valuable for understanding the molecular characteristics of primate retina, as well as the molecular regulation of aging progression and related diseases. ### Competing Interest Statement The authors have declared no competing interest.

Download data

  • Downloaded 615 times
  • Download rankings, all-time:
    • Site-wide: 33,710 out of 118,130
    • In neuroscience: 4,853 out of 18,588
  • Year to date:
    • Site-wide: 10,741 out of 118,130
  • Since beginning of last month:
    • Site-wide: 15,273 out of 118,130

Altmetric data


Downloads over time

Distribution of downloads per paper, site-wide


PanLingua

Sign up for the Rxivist weekly newsletter! (Click here for more details.)


News