Impact of genetic susceptibility to multiple sclerosis on the T cell epigenome: proximal and distal effects
Sarah M Connor,
Belinda J Kaskow,
Lisa F. Barcellos,
Howard L. Weiner,
Philip L. De Jager
Posted 12 Jul 2020
bioRxiv DOI: 10.1101/2020.07.11.198721
Posted 12 Jul 2020
We establish a genome-wide map of DNA methylation quantitative trait locus (mQTL) effects in CD4+ T cells isolated from multiple sclerosis (MS) patients. Utilizing this map in a colocalization analysis, we identify 19 loci where the same haplotype drives both MS susceptibility and local (cis-) DNA methylation. We also identify two distant (trans-) mQTL effects of MS susceptibility loci: (1) a chromosome 16 MS locus affects PRDM8 methylation (a chromosome 4 region not previously associated with MS susceptibility), and (2) the aggregate effect of MS variants in the major histocompatibility complex (MHC, chromosome 6) influences DNA methylation near PRKCA on chromosome 17. Both effects are replicated in independent samples. Overall, we present a new methylome-wide mQTL resource for a key cell type in inflammatory disease research, uncover functional consequences of MS susceptibility variants, including the convergence of MHC risk alleles onto a new gene target involved in predisposition to MS. ### Competing Interest Statement The authors have declared no competing interest.
- Downloaded 68 times
- Download rankings, all-time:
- Site-wide: 90,569 out of 94,912
- In genomics: 5,801 out of 5,955
- Year to date:
- Site-wide: 69,624 out of 94,912
- Since beginning of last month:
- Site-wide: 9,704 out of 94,912
Downloads over time
Distribution of downloads per paper, site-wide
- 18 Dec 2019: We're pleased to announce PanLingua, a new tool that enables you to search for machine-translated bioRxiv preprints using more than 100 different languages.
- 21 May 2019: PLOS Biology has published a community page about Rxivist.org and its design.
- 10 May 2019: The paper analyzing the Rxivist dataset has been published at eLife.
- 1 Mar 2019: We now have summary statistics about bioRxiv downloads and submissions.
- 8 Feb 2019: Data from Altmetric is now available on the Rxivist details page for every preprint. Look for the "donut" under the download metrics.
- 30 Jan 2019: preLights has featured the Rxivist preprint and written about our findings.
- 22 Jan 2019: Nature just published an article about Rxivist and our data.
- 13 Jan 2019: The Rxivist preprint is live!