Evaluation of the immunogenicity of prime-boost vaccination with the replication-deficient viral vectored COVID-19 vaccine candidate ChAdOx1 nCoV-19
Simon P. Graham,
Rebecca K. McLean,
Alexandra J. Spencer,
Jane C Edwards,
Jack W P Hayes,
Amin S Asfor,
Raymond J Owens,
John A Hammond,
Sarah C. Gilbert,
Tobias J Tuthill,
Posted 20 Jun 2020
bioRxiv DOI: 10.1101/2020.06.20.159715 (published DOI: 10.1038/s41541-020-00221-3)
Posted 20 Jun 2020
Clinical development of the COVID-19 vaccine candidate ChAdOx1 nCoV-19, a replication-deficient simian adenoviral vector expressing the full-length SARS-CoV-2 spike (S) protein was initiated in April 2020 following non-human primate studies using a single immunisation. Here, we compared the immunogenicity of one or two doses of ChAdOx1 nCoV-19 in both mice and pigs. Whilst a single dose induced antigen-specific antibody and T cells responses, a booster immunisation enhanced antibody responses, particularly in pigs, with a significant increase in SARS-CoV-2 neutralising titres. ### Competing Interest Statement Sarah Gilbert and Teresa Lambe are named on a patent application covering ChAdOx1 nCoV-19. The remaining authors declare no competing interests. The funders played no role in the conceptualisation, design, data collection, analysis, the decision to publish, or preparation of the manuscript.
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