Rxivist logo

Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 73,081 bioRxiv papers from 318,132 authors.

WASP: allele-specific software for robust discovery of molecular quantitative trait loci

By Bryce van de Geijn, Graham McVicker, Yoav Gilad, Jonathan K. Pritchard

Posted 07 Nov 2014
bioRxiv DOI: 10.1101/011221 (published DOI: 10.1038/nmeth.3582)

Allele-specific sequencing reads provide a powerful signal for identifying molecular quantitative trait loci (QTLs), however they are challenging to analyze and prone to technical artefacts. Here we describe WASP, a suite of tools for unbiased allele-specific read mapping and discovery of molecular QTLs. Using simulated reads, RNA-seq reads and ChIP-seq reads, we demonstrate that our approach has a low error rate and is far more powerful than existing QTL mapping approaches.

Download data

  • Downloaded 3,280 times
  • Download rankings, all-time:
    • Site-wide: 1,119 out of 73,076
    • In genomics: 260 out of 4,853
  • Year to date:
    • Site-wide: 43,462 out of 73,076
  • Since beginning of last month:
    • Site-wide: 43,462 out of 73,076

Altmetric data

Downloads over time

Distribution of downloads per paper, site-wide


Sign up for the Rxivist weekly newsletter! (Click here for more details.)