Recently, increasing studies reported that plant microRNAs (miRNAs) from food could be absorbed through gastrointestinal tract to regulate the physiological processes of animals. These novel cross-kingdom regulatory roles of plant miRNAs open a new field in miRNA study and drug discovery, but the lack of corresponding bioinformatics tools limit the development of this field. In this study, we built a web-based tool, RPRH (Role of Plant microRNA in Human), to infer the potential roles of plant miRNAs in human and to profile the landscape of all documented plant miRNAs regulatory functions in human. Totally, RPRH included 10414 miRNAs from 82 plant species and 18062 annotation terms like diseases, pathway, gene ontology (GO), and drugs. RPRH represents a bioinformatics resource for further investigation of cross-kingdom regulations of plant miRNAs. Availability: http://www.rnanut.net/rprh/ ### Competing Interest Statement The authors have declared no competing interest.
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- 27 Nov 2020: The website and API now include results pulled from medRxiv as well as bioRxiv.
- 18 Dec 2019: We're pleased to announce PanLingua, a new tool that enables you to search for machine-translated bioRxiv preprints using more than 100 different languages.
- 21 May 2019: PLOS Biology has published a community page about Rxivist.org and its design.
- 10 May 2019: The paper analyzing the Rxivist dataset has been published at eLife.
- 1 Mar 2019: We now have summary statistics about bioRxiv downloads and submissions.
- 8 Feb 2019: Data from Altmetric is now available on the Rxivist details page for every preprint. Look for the "donut" under the download metrics.
- 30 Jan 2019: preLights has featured the Rxivist preprint and written about our findings.
- 22 Jan 2019: Nature just published an article about Rxivist and our data.
- 13 Jan 2019: The Rxivist preprint is live!