Hydroxychloroquine Proves Ineffective in Hamsters and Macaques Infected with SARS-CoV-2
Michael A Jarvis,
Patrick W. Hanley,
Brandi N. Williamson,
Catharine M. Bosio,
Emmie de Wit,
Posted 11 Jun 2020
bioRxiv DOI: 10.1101/2020.06.10.145144
Posted 11 Jun 2020
We remain largely without effective prophylactic/therapeutic interventions for COVID-19. Although many human clinical trials are ongoing, there remains a deficiency of supportive preclinical drug efficacy studies. Here we assessed the prophylactic/therapeutic efficacy of hydroxychloroquine (HCQ), a drug of interest for COVID-19 management, in two animal models. When used for prophylaxis or treatment neither the standard human malaria dose (6.5 mg/kg) nor a high dose (50 mg/kg) of HCQ had any beneficial effect on clinical disease or SARS-CoV-2 kinetics (replication/shedding) in the Syrian hamster disease model. Similarly, HCQ prophylaxis/treatment (6.5 mg/kg) did not significantly benefit clinical outcome nor reduce SARS-CoV-2 replication/shedding in the upper and lower respiratory tract in the rhesus macaque disease model. In conclusion, our preclinical animal studies do not support the use of HCQ in prophylaxis/treatment of COVID-19. ### Competing Interest Statement The authors have declared no competing interest.
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