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The reported healthy ageing gene expression score: lack of association in two cohorts

By Luke C Pilling, Lorna W Harries, Dena G. Hernandez, Andrew B. Singleton, George Kuchel, Luigi Ferrucci, David Melzer

Posted 09 Dec 2015
bioRxiv DOI: 10.1101/034058

Sood et al. report a multi-tissue RNA signature "predictive of human health, using only peripheral blood samples". We tested this score in blood in two independent, larger cohorts and found no associations with age or related phenotypes, including muscle strength, interleukin-6 or mortality.

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