Silent dissemination of plasmid-borne tigecycline resistance gene tet(X6) in livestock-associated Acinetobacter towneri
Posted 12 May 2020
bioRxiv DOI: 10.1101/2020.05.08.085514
Posted 12 May 2020
A tigecycline-resistance gene, tet (X6), was detected on a 159-kb novel plasmid carried by a tigecycline-susceptible livestock-associated Acinetobacter towneri isolate. The genetic context of tet (X6) (ΔIS Vsa3-tet (X6)- abh-guaA -IS Vsa3 ) is highly similar with that of the other plasmid-borne tet (X) variants. The 23-Ala residue of the first FAD binding site conferred higher activity to Tet(X6) than the 23-Gly reside conserved in the other plasmid-borne tet (X)s. To our knowledge, this is the first report of tet (X6) carried by the plasmid.
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