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Subcortical Volume Trajectories across the Lifespan: Data from 18,605 healthy individuals aged 3-90 years

By Danai Dima, Efstathios Papachristou, Amirhossein Modabbernia, Gaelle E Doucet, Ingrid Agartz, Moji Aghajani, Theophilus N Akudjedu, Anton Albajes-Eizagirre, Dag Alnæs, Kathryn I Alpert, Micael Andersson, Nancy Andreasen, Ole A. Andreassen, P. Asherson, Tobias Banaschewski, Nuria Bargallo, Sarah Baumeister, Ramona Baur-Streubel, Alessandro Bertolino, Aurora Bonvino, Dorret I. Boomsma, Stefan Borgwardt, Josiane Bourque, Daniel Brandeis, Alan Breier, Henry Brodaty, Rachel M Brouwer, Jan K. Buitelaar, Geraldo F Busatto, Randy L. Buckner, Vincent Calhoun, Erick J Canales-Rodríguez, Dara M. Cannon, Xavier Caseras, Francisco X. Castellanos, Simon Cervenka, Tiffany M Chaim-Avancini, Christopher RK Ching, Vincent P Clark, Patricia Conrod, Annette Conzelmann, Benedicto Crespo-Facorro, Fabrice Crivello, Eveline AM Crone, Anders M. Dale, Cristopher Davey, Eco JC de Geus, Lieuwe de Haan, Greig I. de Zubicaray, Anouk den Braber, Erin W. Dickie, Annabella Di Giorgio, Nhat Trung Doan, Erlend S. Dørum, Stefan Ehrlich, Susanne Erk, Thomas Espeseth, Helena Fatouros-Bergman, Simon E Fisher, Jean-Paul Fouche, Barbara Franke, Thomas Frodl, Paola Fuentes-Claramonte, David C. Glahn, Ian H. Gotlib, Hans-Jörgen Grabe, Oliver Grimm, Nynke A. Groenewold, Dominik Grotegerd, Oliver Gruber, Patricia Gruner, Rachel E Gur, Ruben C. Gur, Ben J. Harrison, Catharine A. Hartman, Sean N Hatton, Andreas Heinz, Dirk J. Heslenfeld, Derrek P. Hibar, Ian B Hickie, Beng-Choon Ho, Pieter J Hoekstra, Sarah Hohmann, Avram J Holmes, Martine Hoogman, Norbert Hosten, Fleur M Howells, Hilleke E Hulshoff Pol, Chaim Huyser, Neda Jahanshad, Anthony James, Jiyang Jiang, Erik G. Jönsson, John A Joska, Rene Kahn, Andrew Kalnin, Ryota Kanai, Sim Kang, Marieke Klein, Tatyana P Klushnik, Laura Koenders, Sanne Koops, Bernd Krämer, J. Kuntsi, Jim Lagopoulos, Luisa Lázaro, Irina Lebedeva, Won Hee Lee, Klaus-Peter Lesch, C Lochner, Marise WJ Machielsen, Sophie Maingault, Nicholas G Martin, Ignacio Martínez-Zalacaín, David Mataix-Cols, Bernard Mazoyer, Colm McDonald, Brenna C McDonald, Andrew M McIntosh, Katie L. McMahon, Genevieve McPhilemy, José M Menchón, Andrew M. McIntosh, Andreas Meyer-Lindenberg, Jilly Naaijen, Pablo Najt, Tomohiro Nakao, Jan E. Nordvik, Lars Nyberg, Jaap Oosterlaan, Víctor Ortiz-García de la Foz, Yannis Paloyelis, Paul Pauli, Giulio Pergola, Edith Pomarol-Clotet, Maria J Portella, Steven G Potkin, Joaquim Radua, Andreas Reif, Joshua L. Roffman, Pedro G.P. Rosa, Matthew D. Sacchet, Perminder S Sachdev, Raymond Salvador, Pascual Sánchez-Juan, Salvador Sarró, Theodore D. Satterthwaite, Andrew J. Saykin, Mauricio H. Serpa, Lianne Schmaal, Knut Schnell, Gunter Schumann, Jordan W Smoller, Iris Sommer, Carles Soriano-Mas, Dan J Stein, Lachlan T. Strike, Suzanne C Swagerman, Christian K. Tamnes, Henk S Temmingh, Sophia I Thomopoulos, Alexander S Tomyshev, Diana Tordesillas-Gutiérrez, Julian N. Trollor, Jessica A. Turner, Anne Uhlmann, Odille A van den Heuvel, Dennis van den Meer, Nic JA van der Wee, Neeltje E.M. van Haren, Dennis van ’t Ent, Theo G.M. van Erp, Ilya M. Veer, Dick J Veltman, Henry Völzke, Henrik Walter, Esther Walton, Lei Wang, Yang Wang, Thomas H. Wassink, Bernd Weber, Wei Wen, John D West, Lars T. Westlye, H.C. Whalley, Lara M Wierenga, Steven CR Williams, Katharina Wittfeld, Daniel H Wolf, Amanda Worker, Margaret J Wright, Kun Yang, Yulyia Yoncheva, Marcus V. Zanetti, Georg C. Ziegler, Paul Thompson, Sophia Frangou

Posted 07 May 2020
bioRxiv DOI: 10.1101/2020.05.05.079475

Age has a major effect on brain volume. However, the normative studies available are constrained by small sample sizes, restricted age coverage and significant methodological variability. These limitations introduce inconsistencies and may obscure or distort the lifespan trajectories of brain morphometry. In response, we capitalised on the resources of the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) Consortium to examine the age-related morphometric trajectories of the ventricles, the basal ganglia (caudate, putamen, pallidum, and nucleus accumbens), the thalamus, hippocampus and amygdala using magnetic resonance imaging data obtained from 18,605 individuals aged 3-90 years. All subcortical structure volumes were at their maximum early in life; the volume of the basal ganglia showed a gradual monotonic decline thereafter while the volumes of the thalamus, amygdala and the hippocampus remained largely stable (with some degree of decline in thalamus) until the sixth decade of life followed by a steep decline thereafter. The lateral ventricles showed a trajectory of continuous enlargement throughout the lifespan. Significant age-related increase in inter-individual variability was found for the hippocampus and amygdala and the lateral ventricles. These results were robust to potential confounders and could be used to derive risk predictions for the early identification of diverse clinical phenotypes. ### Competing Interest Statement The authors have declared no competing interest.

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