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Transcriptome-wide association study of schizophrenia and chromatin activity yields mechanistic disease insights

By Alexander Gusev, Nick Mancuso, Hilary K. Finucane, Yakir Reshef, Lingyun Song, Alexias Safi, Edwin Oh, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Steven McCarroll, Benjamin Neale, Roel Ophoff, Michael C O’Donovan, Nicholas Katsanis, Gregory E. Crawford, Patrick F Sullivan, Bogdan Pasaniuc, Alkes L. Price

Posted 02 Aug 2016
bioRxiv DOI: 10.1101/067355 (published DOI: 10.1038/s41588-018-0092-1)

Genome-wide association studies (GWAS) have identified over 100 risk loci for schizophrenia, but the causal mechanisms remain largely unknown. We performed a transcriptome-wide association study (TWAS) integrating expression data from brain, blood, and adipose tissues across 3,693 individuals with schizophrenia GWAS of 79,845 individuals from the Psychiatric Genomics Consortium. We identified 157 genes with a transcriptome-wide significant association, of which 35 did not overlap a known GWAS locus; the largest number involved alternative splicing in brain. 42/157 genes were also associated to specific chromatin phenotypes measured in 121 independent samples (a 4-fold enrichment over background genes). This high-throughput connection of GWAS findings to specific genes, tissues, and regulatory mechanisms is an essential step toward understanding the biology of schizophrenia and moving towards therapeutic interventions.

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