Rxivist logo

COVID-19, caused by SARS-CoV-2, is an influenza-like disease with a respiratory route of transmission, yet clinical evidence suggests that the intestine may present another viral target organ. Indeed, the SARS-CoV-2 receptor angiotensin converting enzyme 2 (ACE2) is highly expressed on differentiated enterocytes. In human small intestinal organoids, enterocytes were readily infected by SARS-CoV and SARS-CoV-2 as demonstrated by confocal- and electron-microscopy. Consequently, significant titers of infectious viral particles were measured. mRNA expression analysis revealed strong induction of a generic viral response program. We conclude that intestinal epithelium supports SARS-CoV-2 replication. ### Competing Interest Statement H.C. is inventor on multiple patents held by the Dutch Royal Academy of Sciences that cover organoid technology. His full disclosure is given at https://www.uu.nl/staff/JCClevers/. There are no patents derived from this work.

Download data

  • Downloaded 3,502 times
  • Download rankings, all-time:
    • Site-wide: 1,695 out of 106,159
    • In cell biology: 47 out of 5,364
  • Year to date:
    • Site-wide: 468 out of 106,159
  • Since beginning of last month:
    • Site-wide: 9,854 out of 106,159

Altmetric data


Downloads over time

Distribution of downloads per paper, site-wide


PanLingua

Sign up for the Rxivist weekly newsletter! (Click here for more details.)


News