Rxivist logo

A miRNA catalogue and ncRNA annotation of the short-living fish Nothobranchius furzeri

By Mario Baumgart, Emanuel Barth, Aurora Savino, Marco Groth, Philipp Koch, Andreas Petzold, Ivan Arisi, Matthias Platzer, Manja Marz, Alessandro Cellerino

Posted 27 Jan 2017
bioRxiv DOI: 10.1101/103697 (published DOI: 10.1186/s12864-017-3951-8)

Background: The short-lived fish Nothobranchius furzeri is the shortest-lived vertebrate that can be cultured in captivity and was recently established as a model organism for aging research. Small non-coding RNAs, especially miRNAs, are implicated in age-dependent control of gene expression. Results: Here, we present a comprehensive catalogue of miRNAs and several other non-coding RNA classes (ncRNAs) for Nothobranchius furzeri. Analyzing multiple small RNA-Seq libraries, we show most of these identified miRNAs are expressed in at least one of seven Nothobranchius species. Additionally, duplication and clustering of N. furzeri miRNAs was analyzed and compared to the four fish species Danio rerio, Oryzias latipes, Gasterosteus aculeatus and Takifugu rubripes. A peculiar characteristic of N. furzeri as compared to other teleosts was a duplication of the miR-29 cluster. Conclusion: The completeness of the catalogue we provide is comparable to that of zebrafish. This catalogue represents a basis to investigate the role of miRNAs in aging and development in this species.

Download data

  • Downloaded 525 times
  • Download rankings, all-time:
    • Site-wide: 39,777 out of 116,126
    • In genomics: 3,431 out of 6,424
  • Year to date:
    • Site-wide: 93,705 out of 116,126
  • Since beginning of last month:
    • Site-wide: 96,476 out of 116,126

Altmetric data


Downloads over time

Distribution of downloads per paper, site-wide


PanLingua

Sign up for the Rxivist weekly newsletter! (Click here for more details.)


News