Rxivist logo

Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 65,106 bioRxiv papers from 288,545 authors.

Dietary adaptation of FADS genes in Europe varied across time and geography

By Kaixiong Ye, Feng Gao, David Wang, Ofer Bar-Yosef, Alon Keinan

Posted 23 Feb 2017
bioRxiv DOI: 10.1101/111229 (published DOI: 10.1038/s41559-017-0167)

Fatty acid desaturase (FADS) genes encode rate-limiting enzymes for the biosynthesis of omega-6 and omega-3 long chain polyunsaturated fatty acids (LCPUFAs). This biosynthesis is essential for individuals subsisting on LCPUFAs-poor, plant-based diets. Positive selection on FADS genes has been reported in multiple populations, but its presence and pattern in Europeans remain elusive. Here, with analyses of ancient and modern DNA, we demonstrated that positive selection acted on the same FADS variants both before and after the advent of farming in Europe, but on opposite alleles. Selection in recent farmers also varied geographically, with the strongest signal in Southern Europe. These varying selection patterns concur with anthropological evidence of differences in diets, and with the association of recently-adaptive alleles with higher FADS1 expression and enhanced LCPUFAs biosynthesis. Genome-wide association studies revealed associations of recently-adaptive alleles with not only LCPUFAs, but also other lipids and decreased risk of several inflammation-related diseases.

Download data

  • Downloaded 1,492 times
  • Download rankings, all-time:
    • Site-wide: 3,838 out of 65,106
    • In genomics: 703 out of 4,449
  • Year to date:
    • Site-wide: 18,622 out of 65,106
  • Since beginning of last month:
    • Site-wide: 34,495 out of 65,106

Altmetric data

Downloads over time

Distribution of downloads per paper, site-wide

Sign up for the Rxivist weekly newsletter! (Click here for more details.)