Rxivist logo

Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 62,725 bioRxiv papers from 278,303 authors.

Regulation of Life Span by the Gut Microbiota in The Short-Lived African Turquoise Killifish

By Patrick Smith, David Willemsen, Miriam Popkes, Franziska Metge, Edson Gandiwa, Martin Reichard, Dario Riccardo Valenzano

Posted 27 Mar 2017
bioRxiv DOI: 10.1101/120980 (published DOI: 10.7554/eLife.27014)

Gut bacteria occupy the interface between the organism and the external environment, contributing to homeostasis and disease. Yet, the causal role of the gut microbiota during host aging is largely unexplored. Here, using the African turquoise killifish (Nothobranchius furzeri), a naturally short-lived vertebrate, we show that the gut microbiota plays a key role in modulating vertebrate life span. Recolonizing the gut of middle-age individuals with bacteria from young donors resulted in life span extension and delayed behavioral decline. This intervention prevented the decrease in microbial diversity associated with host aging and maintained a young-like gut bacterial community, characterized by overrepresentation of the key genera Exiguobacterium, Planococcus, Propionigenium and Psychrobacter. Our findings demonstrate that the natural microbial gut community of young individuals can causally induce long-lasting beneficial systemic effects that lead to life span extension in a vertebrate model.

Download data

  • Downloaded 14,780 times
  • Download rankings, all-time:
    • Site-wide: 47 out of 62,725
    • In genomics: 13 out of 4,314
  • Year to date:
    • Site-wide: 10,654 out of 62,725
  • Since beginning of last month:
    • Site-wide: 13,007 out of 62,725

Altmetric data


Downloads over time

Distribution of downloads per paper, site-wide


Sign up for the Rxivist weekly newsletter! (Click here for more details.)


News