Comparative Pathogenesis Of COVID-19, MERS And SARS In A Non-Human Primate Model
Mart M. Lamers,
Dennis de Meulder,
Geert van Amerongen,
Judith van den Brand,
Nisreen M.A. Okba,
Peter van Run,
Martje Fentener van Vlissingen,
Rik de Swart,
Bart L. Haagmans
Posted 17 Mar 2020
bioRxiv DOI: 10.1101/2020.03.17.995639 (published DOI: 10.1126/science.abb7314)
Posted 17 Mar 2020
A novel coronavirus, SARS-CoV-2, was recently identified in patients with an acute respiratory syndrome, COVID-19. To compare its pathogenesis with that of previously emerging coronaviruses, we inoculated cynomolgus macaques with SARS-CoV-2 or MERS-CoV and compared with historical SARS-CoV infections. In SARS-CoV-2-infected macaques, virus was excreted from nose and throat in absence of clinical signs, and detected in type I and II pneumocytes in foci of diffuse alveolar damage and mucous glands of the nasal cavity. In SARS-CoV-infection, lung lesions were typically more severe, while they were milder in MERS-CoV infection, where virus was detected mainly in type II pneumocytes. These data show that SARS-CoV-2 can cause a COVID-19-like disease, and suggest that the severity of SARS-CoV-2 infection is intermediate between that of SARS-CoV and MERS-CoV.
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