Mapping the immunogenic landscape of near-native HIV-1 envelope trimers in non-human primates
By
Christopher A Cottrell,
Jelle van Schooten,
Charles A. Bowman,
Meng Yuan,
David Oyen,
Mia Shin,
Robert Morpurgo,
Patricia van der Woude,
Marielle van Breemen,
Jonathan L. Torres,
Raj Patel,
Justin Gross,
Leigh M Sewall,
Jeffrey Copps,
Gabriel Ozorowski,
Bartek Nogal,
Devin Sok,
Eva G Rakasz,
Celia Labranche,
Vladimir Vigdorovich,
Scott Christley,
Diane G. Carnathan,
D. Noah Sather,
DC Montefiori,
Guido Silvestri,
Dennis R. Burton,
John P Moore,
Ian A. Wilson,
Rogier W. Sanders,
Andrew B. Ward,
Marit J. van Gils
Posted 07 Feb 2020
bioRxiv DOI: 10.1101/2020.02.05.936096
(published DOI: 10.1371/journal.ppat.1008753)
The induction of broad and potent immunity by vaccines is the key focus of research efforts aimed at protecting against HIV-1 infection. Soluble native-like HIV-1 envelope glycoproteins have shown promise as vaccine candidates as they can induce potent autologous neutralizing responses in rabbits and non-human primates. In this study, monoclonal antibodies were isolated and characterized from rhesus macaques immunized with the BG505 SOSIP.664 trimer to better understand vaccine-induced antibody responses. Our studies reveal a diverse landscape of antibodies recognizing immunodominant strain-specific epitopes and non-neutralizing neo-epitopes. Additionally, we isolated a subset of mAbs against an epitope cluster at the gp120-gp41 interface that recognize the highly conserved fusion peptide and the glycan at position 88 and have characteristics akin to several human-derived broadly neutralizing antibodies.
Download data
- Downloaded 568 times
- Download rankings, all-time:
- Site-wide: 42,667
- In immunology: 1,157
- Year to date:
- Site-wide: 78,505
- Since beginning of last month:
- Site-wide: 100,847
Altmetric data
Downloads over time
Distribution of downloads per paper, site-wide
PanLingua
News
- 27 Nov 2020: The website and API now include results pulled from medRxiv as well as bioRxiv.
- 18 Dec 2019: We're pleased to announce PanLingua, a new tool that enables you to search for machine-translated bioRxiv preprints using more than 100 different languages.
- 21 May 2019: PLOS Biology has published a community page about Rxivist.org and its design.
- 10 May 2019: The paper analyzing the Rxivist dataset has been published at eLife.
- 1 Mar 2019: We now have summary statistics about bioRxiv downloads and submissions.
- 8 Feb 2019: Data from Altmetric is now available on the Rxivist details page for every preprint. Look for the "donut" under the download metrics.
- 30 Jan 2019: preLights has featured the Rxivist preprint and written about our findings.
- 22 Jan 2019: Nature just published an article about Rxivist and our data.
- 13 Jan 2019: The Rxivist preprint is live!