Rxivist logo

Toward an integrated classification of neuronal cell types: morphoelectric and transcriptomic characterization of individual GABAergic cortical neurons

By Nathan William Gouwens, Staci A. Sorensen, Fahimeh Baftizadeh, Agata Budzillo, Brian R. Lee, Tim Jarsky, Lauren Alfiler, Anton Arkhipov, Katherine Baker, Eliza Barkan, Kyla Berry, Darren Bertagnolli, Kris Bickley, Jasmine Bomben, Thomas Braun, Krissy Brouner, Tamara Casper, Kirsten Crichton, Tanya L. Daigle, Rachel Dalley, Rebecca de Frates, Nick Dee, Tsega Desta, Samuel Dingman Lee, Nadezhda Dotson, Tom Egdorf, Lauren Ellingwood, Rachel Enstrom, Luke Esposito, Colin Farrell, David Feng, Olivia Fong, Rohan Gala, Clare Gamlin, Amanda Gary, Alexandra Glandon, Jeff Goldy, Melissa Gorham, Lucas Graybuck, Hong Gu, Kristen Hadley, Michael J. Hawrylycz, Alex M. Henry, DiJon Hill, Madie Hupp, Sara Kebede, Tae Kyung Kim, Lisa Kim, Matthew Kroll, Changkyu Lee, Katherine E. Link, Matthew Mallory, Rusty Mann, Michelle Maxwell, Medea McGraw, Delissa McMillen, Alice Mukora, Lindsay Ng, Lydia Ng, Kiet Ngo, Philip R. Nicovich, Aaron Oldre, Daniel Park, Hanchuan Peng, Osnat Penn, Thanh Pham, Alice Pom, Lydia Potekhina, Ramkumar Rajanbabu, Shea Ransford, David Reid, Christine Rimorin, Miranda Robertson, Kara Ronellenfitch, Augustin Ruiz, David Sandman, Kimberly Smith, Josef Sulc, Susan M. Sunkin, Aaron Szafer, Michael Tieu, Amy Torkelson, Jessica Trinh, Herman Tung, Wayne Wakeman, Katelyn Ward, Grace Williams, Zhi Zhou, Jonathan T. Ting, Uygar Sumbul, Ed S. Lein, Christof Koch, Zizhen Yao, Bosiljka Tasic, Jim Berg, Gabe Murphy, Hongkui Zeng

Posted 04 Feb 2020
bioRxiv DOI: 10.1101/2020.02.03.932244

Neurons are frequently classified into distinct groups or cell types on the basis of structural, physiological, or genetic attributes. To better constrain the definition of neuronal cell types, we characterized the transcriptomes and intrinsic physiological properties of over 3,700 GABAergic mouse visual cortical neurons and reconstructed the local morphologies of 350 of those neurons. We found that most transcriptomic types (t-types) occupy specific laminar positions within mouse visual cortex, and many of those t-types exhibit consistent electrophysiological and morphological features. We observed that these properties could vary continuously between t-types, which limited the ability to predict specific t-types from other data modalities. Despite that, the data support the presence of at least 20 interneuron met-types that have congruent morphological, electrophysiological, and transcriptomic properties.

Download data

  • Downloaded 3,392 times
  • Download rankings, all-time:
    • Site-wide: 1,462 out of 88,548
    • In neuroscience: 181 out of 15,754
  • Year to date:
    • Site-wide: 289 out of 88,548
  • Since beginning of last month:
    • Site-wide: 3,065 out of 88,548

Altmetric data


Downloads over time

Distribution of downloads per paper, site-wide


PanLingua

Sign up for the Rxivist weekly newsletter! (Click here for more details.)


News