Rxivist logo

DNA methylation age acceleration and risk factors for Alzheimer's disease

By Daniel L. McCartney, Anna J Stevenson, RM Walker, Jude Gibson, Stewart W Morris, Archie Campbell, Alison D Murray, Heather C. Whalley, David J Porteous, Andrew M. McIntosh, Kathryn L. Evans, Ian J Deary, R. E. Marioni

Posted 08 Mar 2018
bioRxiv DOI: 10.1101/278945 (published DOI: 10.1016/j.dadm.2018.05.006)

INTRODUCTION: The 'epigenetic clock' is a DNA methylation based estimate of biological age and is correlated with chronological age: the greatest risk factor for Alzheimer's disease (AD). Genetic and environmental risk factors exist for AD, several of which are potentially modifiable. Here, we assess the relationship associations between the epigenetic clock and AD risk factors. METHODS: Linear mixed modelling was used to assess the relationship between age acceleration (the residual of biological age regressed onto chronological age) and AD risk factors relating to cognitive reserve, lifestyle, disease, and genetics in the Generation Scotland study (n=5,100). RESULTS: We report significant associations between the epigenetic clock and BMI, total:HDL cholesterol ratios, socioeconomic status, and smoking behaviour (Bonferroni adjusted P<0.05). DISCUSSION: Associations are present between environmental risk factors for AD and age acceleration. Measures to modify such risk factors might improve the risk profile for AD and the rate of biological ageing. Future longitudinal analyses are therefore warranted.

Download data

  • Downloaded 545 times
  • Download rankings, all-time:
    • Site-wide: 39,040 out of 117,931
    • In genomics: 3,317 out of 6,427
  • Year to date:
    • Site-wide: 88,089 out of 117,931
  • Since beginning of last month:
    • Site-wide: 93,106 out of 117,931

Altmetric data


Downloads over time

Distribution of downloads per paper, site-wide


PanLingua

Sign up for the Rxivist weekly newsletter! (Click here for more details.)


News