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Genome-wide association study identifies 143 loci associated with 25 hydroxyvitamin D concentration.

By Joana A Revez, Tian Lin, Zhen Qiao, Angli Xue, Yan Holtz, Zhihong Zhu, Jian Zeng, Huanwei Wang, Julia Sidorenko, Kathryn E Kemper, Anna AE Vinkhuyzen, Julanne Frater, Darryl Eyles, Thomas HJ Burne, Brittany Mitchell, Nicholas G Martin, Gu Zhu, Peter M Visscher, Jian Yang, Naomi R Wray, John J McGrath

Posted 06 Dec 2019
bioRxiv DOI: 10.1101/860767

Vitamin D deficiency is a candidate risk factor for a range of adverse health outcomes. In a genome-wide association study of 25 hydroxyvitamin D (25OHD) concentration in 417,580 Europeans we identified 143 independent loci in 112 1-Mb regions providing new insights into the physiology of vitamin D and implicating genes involved in (a) lipid and lipoprotein metabolism, (b) dermal tissue properties, and (c) the sulphonation and glucuronidation of 25OHD. Mendelian randomization models found no robust evidence that 25OHD concentration had causal effects on candidate phenotypes (e.g. BMI, psychiatric disorders), but many phenotypes had (direct or indirect) causal effects on 25OHD concentration, clarifying the relationship between 25OHD status and health.

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