DNA methylation in the APOE gene: its link with Alzheimer's and cardiovascular health
Daniel L. McCartney,
Rosie M. Walker,
Mairead L. Bermingham,
Stewart W Morris,
David J. Porteous,
Andrew M. McIntosh,
Kathryn L Evans,
Riccardo E. Marioni
Posted 21 Oct 2019
bioRxiv DOI: 10.1101/811224
Posted 21 Oct 2019
Genetic variation in the apolipoprotein E (APOE) gene is associated with Alzheimer's disease (AD) and risk factors for cardiovascular disease (CVD). DNA methylation at APOE has been linked to altered cognition and AD. It is unclear if epigenetic marks could be used for predicting future disease. We assessed blood-based DNA methylation at 13 CpGs in the APOE gene in 5828 participants from the Generation Scotland (GS) cohort. Using linear regression, we examined the relationship between APOE methylation, cognition, cholesterol, and the risks for AD and CVD. DNA methylation at two CpGs was associated with the ratio of total-to-HDL cholesterol, but not with cognition, or the risks of AD or CVD. APOE methylation could be involved in the levels of blood cholesterol, but there is no evidence for the utility of APOE methylation as a biomarker for predicting AD or CVD.
- Downloaded 172 times
- Download rankings, all-time:
- Site-wide: 77,990 out of 94,912
- In neuroscience: 13,931 out of 16,862
- Year to date:
- Site-wide: 64,065 out of 94,912
- Since beginning of last month:
- Site-wide: 56,430 out of 94,912
Downloads over time
Distribution of downloads per paper, site-wide
- 18 Dec 2019: We're pleased to announce PanLingua, a new tool that enables you to search for machine-translated bioRxiv preprints using more than 100 different languages.
- 21 May 2019: PLOS Biology has published a community page about Rxivist.org and its design.
- 10 May 2019: The paper analyzing the Rxivist dataset has been published at eLife.
- 1 Mar 2019: We now have summary statistics about bioRxiv downloads and submissions.
- 8 Feb 2019: Data from Altmetric is now available on the Rxivist details page for every preprint. Look for the "donut" under the download metrics.
- 30 Jan 2019: preLights has featured the Rxivist preprint and written about our findings.
- 22 Jan 2019: Nature just published an article about Rxivist and our data.
- 13 Jan 2019: The Rxivist preprint is live!