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Structural Brain Imaging Studies Offer Clues about the Effects of the Shared Genetic Etiology among Neuropsychiatric Disorders
Nevena V. Radonjić,
Jonathan L. Hess,
Jan K. Buitelaar,
Christopher R. K. Ching,
Sanjay M Sisodiya,
Dan J Stein,
Odile A. van den Heuvel,
Theo G.M. van Erp,
Daan van Rooij,
Dick J. Veltman,
Stephen V. Faraone
Posted 17 Oct 2019
bioRxiv DOI: 10.1101/809582
Posted 17 Oct 2019
Background Genomewide association studies have found significant genetic correlations among many neuropsychiatric disorders. In contrast, we know much less about the degree to which structural brain alterations are similar among disorders and, if so, the degree to which such similarities have a genetic etiology. Methods From the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) consortium, we acquired standardized mean differences (SMDs) in regional brain volume and cortical thickness between cases and controls. We had data on 41 brain regions for: attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), bipolar disorder (BD), epilepsy, major depressive disorder (MDD), obsessive compulsive disorder (OCD) and schizophrenia (SCZ). These data had been derived from 24,360 patients and 37,425 controls. Results The SMDs were significantly correlated between SCZ and BD, OCD, MDD, and ASD. MDD was positively correlated with BD and OCD. BD was positively correlated with OCD and negatively correlated with ADHD. These pairwise correlations among disorders were significantly correlated with the corresponding pairwise correlations among disorders derived from genomewide association studies ( r = 0.494; p = 0.025). Conclusions Our results show substantial similarities in sMRI phenotypes among neuropsychiatric disorders and suggest that these similarities are accounted for, in part, by corresponding similarities in common genetic variant architectures.
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