The RNA Atlas, a single nucleotide resolution map of the human transcriptome
Francisco Avila Cobos,
Thomas B Hansen,
Ken R. Bracke,
Tim De Meyer,
Marc R. Wilkins,
Katleen De Preter,
Gary P Schroth,
Posted 17 Oct 2019
bioRxiv DOI: 10.1101/807529
Posted 17 Oct 2019
The human transcriptome consists of various RNA biotypes including multiple types of non-coding RNAs (ncRNAs). Current ncRNA compendia remain incomplete partially because they are almost exclusively derived from the interrogation of small- and polyadenylated RNAs. Here, we present a more comprehensive atlas of the human transcriptome that is derived from matching polyA-, total-, and small-RNA profiles of a heterogeneous collection of nearly 300 human tissues and cell lines. We report on thousands of novel RNA species across all major RNA biotypes, including a hitherto poorly-cataloged class of non-polyadenylated single-exon long non-coding RNAs. In addition, we exploit intron abundance estimates from total RNA-sequencing to test and verify functional regulation by novel non-coding RNAs. Our study represents a substantial expansion of the current catalogue of human ncRNAs and their regulatory interactions. All data, analyses, and results are available in the R2 web portal and serve as a basis to further explore RNA biology and function.
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