White matter microstructure in attention-deficit/hyperactivity disorder: a systematic tractography study in 654 individuals
By
Christienne G. Damatac,
Roselyne J. Chauvin,
Marcel P. Zwiers,
Daan van Rooij,
Sophie E.A. Akkermans,
Jilly Naaijen,
Pieter Hoekstra,
Catharina A Hartman,
Jaap Oosterlaan,
Barbara Franke,
Jan K. Buitelaar,
Christian F Beckmann,
Emma Sprooten
Posted 30 Sep 2019
bioRxiv DOI: 10.1101/787713
(published DOI: 10.1016/j.bpsc.2020.07.015)
Background Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by age-inappropriate levels of inattention and/or hyperactivity-impulsivity (HI). ADHD has been related to differences in white matter (WM) microstructure. However, much remains unclear regarding the nature of these WM differences, and which clinical aspects of ADHD they reflect. We systematically investigated if FA is associated with current and/or lifetime categorical diagnosis, impairment in daily life, and continuous ADHD symptom measures. Methods Diffusion-weighted imaging (DWI) data were obtained from 654 participants (322 unaffected, 258 affected, 74 subthreshold; 7-29 years of age). We applied automated global probabilistic tractography on 18 major WM pathways. Linear mixed effects regression models were used to examine associations of clinical measures with overall brain and tract-specific fractional anisotropy (FA). Results There were significant interactions of tract with all ADHD variables on FA. There were no significant associations of FA with current or lifetime diagnosis, nor with impairment. Lower FA in the right cingulum’s angular bundle (rCAB) was associated with higher hyperactivity/impulsivity symptom severity (PFWE=0.045). There were no significant effects for other tracts. Conclusions This is the first time global probabilistic tractography has been applied to an ADHD dataset of this size. We found no evidence for altered FA in association with ADHD diagnosis. Our findings indicate that associations of FA with ADHD are not uniformly distributed across WM tracts. Continuous symptom measures of ADHD may be more sensitive to FA than diagnostic categories. The rCAB in particular may play a role in symptoms of hyperactivity and impulsivity.
Download data
- Downloaded 427 times
- Download rankings, all-time:
- Site-wide: 62,987
- In neuroscience: 9,499
- Year to date:
- Site-wide: 60,632
- Since beginning of last month:
- Site-wide: 76,213
Altmetric data
Downloads over time
Distribution of downloads per paper, site-wide
PanLingua
News
- 27 Nov 2020: The website and API now include results pulled from medRxiv as well as bioRxiv.
- 18 Dec 2019: We're pleased to announce PanLingua, a new tool that enables you to search for machine-translated bioRxiv preprints using more than 100 different languages.
- 21 May 2019: PLOS Biology has published a community page about Rxivist.org and its design.
- 10 May 2019: The paper analyzing the Rxivist dataset has been published at eLife.
- 1 Mar 2019: We now have summary statistics about bioRxiv downloads and submissions.
- 8 Feb 2019: Data from Altmetric is now available on the Rxivist details page for every preprint. Look for the "donut" under the download metrics.
- 30 Jan 2019: preLights has featured the Rxivist preprint and written about our findings.
- 22 Jan 2019: Nature just published an article about Rxivist and our data.
- 13 Jan 2019: The Rxivist preprint is live!