Exploring the Links between Specific Depression Symptoms and Brain Structure: A Network Study

The network approach to psychopathology has recently received considerable attention, and is as a novel way of conceptualizing mental disorders as causally interacting symptoms. In this study, we modeled a joint network of depression symptoms and depression-related brain structures, using 21 symptoms and five regional brain measures. We used a mixed sample of 268 individuals previously treated for one or more major depressive episodes and never depressed individuals. The network revealed associations between brain structure and unique depressive symptoms, which may clarify relationships regarding symptomatic and biological heterogeneity in depression.

Download data

• Downloaded 469 times
• Download rankings, all-time:
  • Site-wide: 56,847
  • In neuroscience: 8,441
• Year to date:
  • Site-wide: 66,931
• Since beginning of last month:
  • Site-wide: 51,511

Altmetric data

Downloads over time

Distribution of downloads per paper, site-wide