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The nervous system is the major target for Gold nanoparticles: Evidence from RNA sequencing data of C. elegans

By Jihao Mo, Ning Sun, Baolin Yang, Shaoxia Li, Lei Wang

Posted 11 Jul 2019
bioRxiv DOI: 10.1101/699785

The increasing use of gold nanoparticles (NPs) raises concerns about the potential effect of gold NPs exposure on human health. Therefore, gold NPs exposure is hard to evaluate at the organ level with current measurement technology. The bio-distribution assay showed that intestine was the organ with most gold NPs accumulated in C. elegans . However, our data indicated that 62.8% of the significant altered genes were function in the nervous system using tissue enrichment analysis. Notably, developmental stage analysis has demonstrated that NP exposure interfered with the development of animals. Furthermore, the transcription factors DAF-16 was regulating the oxidative stress genes induced by gold NPs. Therefore, we proposed the localization of the oxidative stress genes in the neuron cells and how their expression affect neuron communication. Our results demonstrate that the gold NPs-induced oxidative stress affects the nervous system via physical damage to the neurons and disruption of cell-to-cell communication. Future toxicology research on gold NPs should focus on neurons. ![Figure][1]</img> Graphical abstract [1]: pending:yes

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