Rxivist logo

Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 65,305 bioRxiv papers from 289,273 authors.

Widespread associations between grey matter structure and the human phenome

By Baptiste Couvy-Duchesne, Lachlan T. Strike, Futao Zhang, Yan Holtz, Zhili Zheng, Kathryn E. Kemper, Loic Yengo, Olivier Colliot, Margaret J Wright, Naomi R. Wray, Jian Yang, Peter M. Visscher

Posted 09 Jul 2019
bioRxiv DOI: 10.1101/696864

The recent availability of large-scale neuroimaging cohorts (here the UK Biobank [UKB] and the Human Connectome Project [HCP]) facilitates deeper characterisation of the relationship between phenotypic and brain architecture variation in humans. We tested the association between 654,386 vertex-wise measures of cortical and subcortical morphology (from T1w and T2w MRI images) and behavioural, cognitive, psychiatric and lifestyle data. We found a significant association of grey-matter structure with 58 out of 167 UKB phenotypes spanning substance use, blood assay results, education or income level, diet, depression, being a twin as well as cognition domains (UKB discovery sample: N=9,888). Twenty-three of the 58 associations replicated (UKB replication sample: N=4,561; HCP, N=1,110). In addition, differences in body size (height, weight, BMI, waist and hip circumference, body fat percentage) could account for a substantial proportion of the association, providing possible insight into previous MRI case-control studies for psychiatric disorders where case status is associated with body mass index. Using the same linear mixed model, we showed that most of the associated characteristics (e.g. age, sex, body size, diabetes, being a twin, maternal smoking, body size) could be significantly predicted using all the brain measurements in out-of-sample prediction. Finally, we demonstrated other applications of our approach including a Region Of Interest (ROI) analysis that retain the vertex-wise complexity and ranking of the information contained across MRI processing options.

Download data

  • Downloaded 510 times
  • Download rankings, all-time:
    • Site-wide: 19,816 out of 65,305
    • In neuroscience: 3,329 out of 11,706
  • Year to date:
    • Site-wide: 5,588 out of 65,305
  • Since beginning of last month:
    • Site-wide: 4,516 out of 65,305

Altmetric data


Downloads over time

Distribution of downloads per paper, site-wide


Sign up for the Rxivist weekly newsletter! (Click here for more details.)


News