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Bacterial fucosidase enables the production of Bombay red blood cells

By Tiansheng Li, Juan Ye, Lei Wang, Lin Zou, Yameng Guo, Linlin Hou, Danfeng Shen, Xiaohong Cai, Haobo Huang, Guiqin Sun, Li Chen

Posted 08 Jul 2019
bioRxiv DOI: 10.1101/695213

We present a method to produce H antigen-deficient red blood cells (RBCs) for transfusion to individuals with anti-H antibodies. A fucosidase from bacteria was heterologously expressed efficiently in E. coli and has been demonstrated to completely remove H antigens on the surface of human RBCs in a facile conversion process. The approach we describe here holds promise for making H-deficient RBCs available for a rare population beyond ABO types.

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