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Brain state stability during working memory is explained by network control theory, modulated by dopamine D1/D2 receptor function, and diminished in schizophrenia

By Urs Braun, Anais Harneit, Giulio Pergola, Tommaso Menara, Axel Schaefer, Richard F. Betzel, Zhenxiang Zang, Janina I. Schweiger, Kristina Schwarz, Junfang Chen, Giuseppe Blasi, Alessandro Bertolino, Daniel Durstewitz, Fabio Pasqualetti, Emanuel Schwarz, Andreas Meyer-Lindenberg, Danielle S Bassett, Heike Tost

Posted 23 Jun 2019
bioRxiv DOI: 10.1101/679670

Dynamical brain state transitions are critical for flexible working memory but the network mechanisms are incompletely understood. Here, we show that working memory entails brain-wide switching between activity states. The stability of states relates to dopamine D1 receptor gene expression while state transitions are influenced by D2 receptor expression and pharmacological modulation. Schizophrenia patients show altered network control properties, including a more diverse energy landscape and decreased stability of working memory representations.

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