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Bacterial Controller Aided Wound Healing: A Case Study in Dynamical Population Controller Design

By Leopold N Green, Chelsea Y. Hu, Xinying Ren, Richard M. Murray

Posted 04 Jun 2019
bioRxiv DOI: 10.1101/659714

Wound healing is a complicated biological process consisting of many types of cellular dy- namics and functions regulated by chemical and molecular signals. Recent advances in synthetic biology have made it possible to predictably design and build closed-loop controllers that can function appropriately alongside biological species. In this paper we develop a simple dynamical population model mimicking the sequential relay-like dynamics of cellular populations involved in the wound healing process. Our model consists of four nodes and five signals whose pa- rameters we can tune to simulate various chronic healing conditions. We also develop a set of regulator functions based on type-1 incoherent feed forward loops (IFFL) that can sense the change from acute healing to incomplete chronic wounds, improving the system in a timely manner. Both the wound healing and type-1 IFFL controller architectures are compatible with available synthetic biology experimental tools for potential applications. ### Competing Interest Statement The authors have declared no competing interest.

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