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Bottom-up ecology of the human microbiome: from metagenomes to metabolomes

By Daniel R. Garza, Marcel C. Van Verk, Martijn A. Huynen, Bas E. Dutilh

Posted 24 Jun 2016
bioRxiv DOI: 10.1101/060673 (published DOI: 10.1038/s41564-018-0124-8)

The environmental metabolome is a dominant and essential factor shaping microbial communities. Thus, we hypothesized that metagenomic datasets could reveal the quantitative metabolic status of a given sample. Using a newly developed bottom-up ecology algorithm, we predicted high-resolution metabolomes of hundreds of metagenomic datasets from the human microbiome, revealing body-site specific metabolomes consistent with known metabolomics data, and suggesting that common cosmetics ingredients are some of the major metabolites shaping the human skin microbiome.

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