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Varapp: A reactive web-application for variants filtering

By Julien Delafontaine, Alexandre Masselot, Robin Liechti, Dmitry Kuznetsov, Ioannis Xenarios, Sylvain Pradervand

Posted 28 Jun 2016
bioRxiv DOI: 10.1101/060806

Summary: Varapp is an open-source web application to filter variants from large sets of exome data stored in a relational database. Varapp offers a reactive graphical user interface, very fast data processing, security and facility to save, reproduce and share results. Typically, a few seconds suffice to apply non-trivial filters to a set of half a million variants and extract a handful of potential clinically relevant targets. Varapp implements different scenarios for Mendelian diseases (dominant, recessive, de novo, X-linked, and compound heterozygous), and allows searching for variants in genes or chromosomal regions of interest. Availability: The application is made of a Javascript front-end and a Python back-end. Its source code is hosted at https://github.com/varapp. A demo version is available at https://varapp-demo.vital-it.ch. The full documentation can be found at https://varapp-demo.vital-it.ch/docs.

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