Rxivist logo

Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 67,594 bioRxiv papers from 298,144 authors.

Delivering genes across the blood-brain barrier: LY6A, a novel cellular receptor for AAV-PHP.B capsids

By Qin Huang, Ken Y Chan, Isabelle G. Tobey, Yujia Alina Chan, Tim Poterba, Christine L Boutros, Alejandro B. Balazs, Richard Daneman, Jonathan M Bloom, Cotton Seed, Benjamin E Deverman

Posted 01 Feb 2019
bioRxiv DOI: 10.1101/538421 (published DOI: 10.1371/journal.pone.0225206)

The engineered AAV-PHP.B family of adeno-associated virus efficiently delivers genes throughout the mouse central nervous system. To guide their application across disease models, and to inspire the development of translational gene therapy vectors useful for targeting neurological diseases in humans, we sought to elucidate the host factors responsible for the CNS tropism of AAV-PHP.B vectors. Leveraging CNS tropism differences across mouse strains, we conducted a genome-wide association study, and rapidly identified and verified LY6A as an essential receptor for the AAV-PHP.B vectors in brain endothelial cells. Importantly, this newly discovered mode of AAV binding and transduction is independent of other known AAV receptors and can be imported into different cell types to confer enhanced transduction by the AAV-PHP.B vectors.

Download data

  • Downloaded 3,274 times
  • Download rankings, all-time:
    • Site-wide: 1,009 out of 67,594
    • In neuroscience: 142 out of 12,116
  • Year to date:
    • Site-wide: 207 out of 67,594
  • Since beginning of last month:
    • Site-wide: 573 out of 67,594

Altmetric data

Downloads over time

Distribution of downloads per paper, site-wide

Sign up for the Rxivist weekly newsletter! (Click here for more details.)