Rxivist logo

Neuroticism as a predictor of frailty in old age: a genetically informative approach

By Hilda Bjork Danielsdottir, Juulia Jylhävä, Sara Hägg, Yi Lu, Lucia Colodro-Conde, Nicholas G Martin, Nancy L Pedersen, Miriam A. Mosing, Kelli Lehto

Posted 26 Jan 2019
bioRxiv DOI: 10.1101/527135 (published DOI: 10.1097/PSY.0000000000000742)

Objective: Neuroticism is associated with poor health outcomes, but its contribution to the accumulation of health deficits in old age, i.e. frailty, is largely unknown. We aimed to explore associations between neuroticism and frailty cross-sectionally and over up to 29 years, and to investigate the contribution of shared genetic influences. Method: Data were derived from the UK Biobank (UKB, n=502,631), the Australian Over 50s Study (AO50, n=3,011) and the Swedish Twin Registry (SALT n=23,744, SATSA n=1,637). Associations between neuroticism and the Frailty Index were investigated using regression analysis cross-sectionally in UKB, AO50 and SATSA, and longitudinally in SALT (25-29y follow-up) and SATSA (6 and 23y follow-up). The co-twin control method was applied to explore the contribution of underlying shared familial factors (SALT, SATSA, AO50). Genome-wide polygenic risk scores for neuroticism in all samples were used to further assess whether common genetic variants associated with neuroticism predict frailty. Results: High neuroticism was consistently associated with greater frailty cross-sectionally (adjusted β, 95% confidence intervals in UKB= 0.32, 0.32-0.33; AO50= 0.35, 0.31-0.39; SATSA= 0.33, 0.27-0.39) and longitudinally up to 29 years (SALT= 0.24; 0.22-0.25; SATSA 6y= 0.31, 0.24-0.38; SATSA 23y= 0.16, 0.07-0.25). When controlling for underlying shared genetic and environmental factors the neuroticism-frailty association remained significant, although decreased. Polygenic risk scores for neuroticism significantly predicted frailty in the two larger samples (meta-analyzed total β= 0.06, 0.05-0.06). Conclusion: High neuroticism is associated with the development and course of frailty. Both environmental and genetic influences, including neuroticism-associated genetic variants, contribute to this relationship.

Download data

  • Downloaded 160 times
  • Download rankings, all-time:
    • Site-wide: 64,566 out of 76,870
    • In epidemiology: 1,306 out of 1,556
  • Year to date:
    • Site-wide: 74,824 out of 76,870
  • Since beginning of last month:
    • Site-wide: 73,067 out of 76,870

Altmetric data


Downloads over time

Distribution of downloads per paper, site-wide


PanLingua

Sign up for the Rxivist weekly newsletter! (Click here for more details.)


News