Rxivist logo

Brain xQTL Map: Integrating The Genetic Architecture Of The Human Brain Transcriptome And Epigenome

By B Ng, CC White, H Klein, SK Sieberts, C McCabe, E Patrick, J Xu, L Yu, C Gaiteri, DA Bennett, Sara Mostafavi, De Jager PL

Posted 27 May 2017
bioRxiv DOI: 10.1101/142927

We perform quantitative trait locus (xQTL) analyses on a multi-omic dataset, comprising RNA sequence, DNA methylation, and histone acetylation ChIP sequence data from the dorsolateral prefrontal cortex of 411 older adult individuals. We identify SNPs that are significantly associated with gene expression, DNA methylation, and histone modification levels. Many SNPs influence more than one type of molecular feature, and epigenetic features are shown to mediate eQTLs in a number of (9%) such loci. We illustrate the utility of our new resource, xQTL Serve, in prioritizing the cell type most affected by an xQTL and in enhancing genome wide association studies (GWAS) as we report 18 additional CNS disease susceptibility loci after re-analyzing published studies.

Download data

  • Downloaded 1,545 times
  • Download rankings, all-time:
    • Site-wide: 8,860 out of 117,931
    • In bioinformatics: 1,144 out of 9,553
  • Year to date:
    • Site-wide: 96,605 out of 117,931
  • Since beginning of last month:
    • Site-wide: 112,647 out of 117,931

Altmetric data


Downloads over time

Distribution of downloads per paper, site-wide


PanLingua

Sign up for the Rxivist weekly newsletter! (Click here for more details.)


News