Rxivist logo

OGRE: Overlap Graph-based metagenomic Read clustEring

By Marleen Balvert, Tina Hauptfeld, Alexander Schönhuth, Bas E. Dutilh

Posted 03 Jan 2019
bioRxiv DOI: 10.1101/511014 (published DOI: 10.1093/bioinformatics/btaa760)

The microbes that live in an environment can be identified from the genomic material that is present, also referred to as the metagenome. Using Next Generation Sequencing techniques this genomic material can be obtained from the environment, resulting in a large set of sequencing reads. A proper assembly of these reads into contigs or even full genomes allows one to identify the microbial species and strains that live in the environment. Assembling a metagenome is a challenging task and can benefit from clustering the reads into species-specific bins prior to assembly. In this paper we propose OGRE, an Overlap-Graph based Read clustEring procedure for metagenomic read data. OGRE is the only method that can successfully cluster reads in species-specific bins for large metagenomic datasets without running into computation time- or memory issues.

Download data

  • Downloaded 443 times
  • Download rankings, all-time:
    • Site-wide: 49,677 out of 118,130
    • In bioinformatics: 5,222 out of 9,572
  • Year to date:
    • Site-wide: 80,176 out of 118,130
  • Since beginning of last month:
    • Site-wide: 103,243 out of 118,130

Altmetric data


Downloads over time

Distribution of downloads per paper, site-wide


PanLingua

Sign up for the Rxivist weekly newsletter! (Click here for more details.)


News