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SQUID: Transcriptomic Structural Variation Detection from RNA-seq

By Cong Ma, Mingfu Shao, Carleton Kingsford

Posted 12 Jul 2017
bioRxiv DOI: 10.1101/162776 (published DOI: 10.1186/s13059-018-1421-5)

Transcripts are frequently modified by structural variations, which leads to a fused transcript of either multiple genes (known as a fusion gene) or a gene and a previously non-transcribing sequence. Detecting these modifications (called transcriptomic structural variations, or TSVs), especially in cancer tumor sequencing, is an important and challenging computational problem. We introduce SQUID, a novel algorithm to accurately predict both fusion-gene and non-fusion-gene TSVs from RNA-seq alignments. SQUID unifies both concordant and discordant read alignments into one model, and doubles the accuracy on simulation data compared to other approaches. With SQUID, we identified novel non-fusion-gene TSVs on TCGA samples.

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