Rxivist logo

Altered cortical brain structure and increased risk for disease seen decades after perinatal exposure to maternal smoking: A study of 9,000 adults in the UK Biobank

By Lauren E. Salminen, Rand R. Wilcox, Alyssa H Zhu, Brandalyn C Riedel, Christopher R. K. Ching, Faisal Rashid, Sophia I. Thomopoulos, Arvin Saremi, Marc B Harrison, Anjanibhargavi Ragothaman, Victoria Knight, Christina P Boyle, Sarah E. Medland, Paul M. Thompson, Neda Jahanshad

Posted 16 Nov 2018
bioRxiv DOI: 10.1101/471839

Secondhand smoke exposure is a major public health risk that is especially harmful to the developing brain, but it is unclear if early life smoke exposure affects brain structure during middle age and older adulthood. Here we analyzed brain MRI data from the UK Biobank in a population-based sample of individuals (ages 44-80) who were exposed (n=2,510) or unexposed (n=6,079) to maternal smoking around birth. We used robust statistical models, including quantile regressions, to test the effect of perinatal smoke exposure (PSE) on cortical surface area (SA), thickness, and subcortical volume. We hypothesized that PSE would be associated with cortical disruption in primary sensory areas compared to unexposed (PSE-) adults. After adjusting for multiple comparisons, SA was significantly lower in the pericalcarine (PCAL), inferior parietal (IPL), and regions of the temporal and frontal cortex of PSE+ adults; these abnormalities were associated with increased risk for several diseases, including circulatory and endocrine conditions. Sensitivity analyses conducted in a hold-out group of healthy participants (exposed, n=109, unexposed, n=315) replicated the effect of PSE on SA in the PCAL and IPL. Collectively our results show a negative, long term effect of PSE on sensory cortices that may increase risk for disease later in life.

Download data

  • Downloaded 261 times
  • Download rankings, all-time:
    • Site-wide: 49,103 out of 76,820
    • In neuroscience: 8,695 out of 13,769
  • Year to date:
    • Site-wide: 63,848 out of 76,820
  • Since beginning of last month:
    • Site-wide: 56,780 out of 76,820

Altmetric data


Downloads over time

Distribution of downloads per paper, site-wide


PanLingua

Sign up for the Rxivist weekly newsletter! (Click here for more details.)


News