Genome-wide association and functional studies identify 46 novel loci for alcohol consumption and suggest common genetic mechanisms with neuropsychiatric disorders
By
Evangelos Evangelou,
He Gao,
Congying Chu,
Georgios Ntritsos,
Paul Blakeley,
Andrew R Butts,
Raha Pazoki,
Hideaki Suzuki,
Fotios Koskeridis,
Andrianos M Yiorkas,
Ibrahim Karaman,
Joshua Elliott,
Stefanie Aeschbacher,
Traci M Bartz,
Sebastian E Baumeister,
Peter S. Braund,
Michael R Brown,
Jennifer A Brody,
Toni-Kim Clarke,
Niki Dimou,
Jessica D. Faul,
Georg Homuth,
Anne U. Jackson,
Katherine A Kentistou,
Peter K Joshi,
Rozenn N. Lemaitre,
Penelope A. Lind,
Leo-Pekka Lyytikäinen,
Massimo Mangino,
Yuri Milaneschi,
Christopher P Nelson,
Ilja M. Nolte,
Mia-Maria Perälä,
Ozren Polasek,
David Porteous,
Scott M Ratliff,
Jennifer A. Smith,
Alena Stančáková,
Alexander Teumer,
Samuli Tuominen,
Sébastien Thériault,
Jagadish Vangipurapu,
John B. Whitfield,
Alexis Wood,
Jie Yao,
Bing Yu,
Wei Zhao,
Dan E. Arking,
Juha Auvinen,
Chunyu Liu,
Minna Männikkö,
Lorenz Risch,
Jerome I. Rotter,
Harold Snieder,
Juha Veijola,
Alexandra I Blakemore,
Michael Boehnke,
Harry Campbell,
David Conen,
Johan G. Eriksson,
Hans J. Grabe,
Xiuqing Guo,
Pim van der Harst,
Catharina A. Hartman,
Caroline Hayward,
Andrew C. Heath,
Marjo-Riitta Jarvelin,
Mika Kähönen,
Sharon LR Kardia,
Michael Kühne,
Johanna Kuusisto,
Markku Laakso,
Jari Lahti,
Terho Lehtimäki,
Andrew M. McIntosh,
Karen L. Mohlke,
Alanna C. Morrison,
Nicholas G Martin,
Albertine J. Oldehinkel,
Brenda W. J. H. Pennix,
Bruce M. Psaty,
Olli T. Raitakari,
Igor Rudan,
Nilesh J. Samani,
Laura J Scott,
Tim D Spector,
Niek Verweij,
David R. Weir,
James F Wilson,
Daniel Levy,
Ioanna Tzoulaki,
Jimmy D Bell,
Paul Matthews,
Adrian Rothenfluh,
Sylvane Desrivières,
Gunter Schumann,
Paul Elliott
Posted 30 Oct 2018
bioRxiv DOI: 10.1101/453332
Excessive alcohol consumption is one of the main causes of death and disability worldwide. Alcohol consumption is a heritable complex trait. We conducted a genome-wide association study (GWAS) of alcohol use in ~480,000 people of European descent to decipher the genetic architecture of alcohol intake. We identified 46 novel, common loci, and investigated their potential functional significance using magnetic resonance imaging data, gene expression and behavioral studies in Drosophila. Our results identify new genetic pathways associated with alcohol consumption and suggest common genetic mechanisms with several neuropsychiatric disorders including schizophrenia.
Download data
- Downloaded 998 times
- Download rankings, all-time:
- Site-wide: 9,340 out of 76,906
- In genetics: 678 out of 4,151
- Year to date:
- Site-wide: 25,055 out of 76,906
- Since beginning of last month:
- Site-wide: 32,377 out of 76,906
Altmetric data
Downloads over time
Distribution of downloads per paper, site-wide
PanLingua
News
- 18 Dec 2019: We're pleased to announce PanLingua, a new tool that enables you to search for machine-translated bioRxiv preprints using more than 100 different languages.
- 21 May 2019: PLOS Biology has published a community page about Rxivist.org and its design.
- 10 May 2019: The paper analyzing the Rxivist dataset has been published at eLife.
- 1 Mar 2019: We now have summary statistics about bioRxiv downloads and submissions.
- 8 Feb 2019: Data from Altmetric is now available on the Rxivist details page for every preprint. Look for the "donut" under the download metrics.
- 30 Jan 2019: preLights has featured the Rxivist preprint and written about our findings.
- 22 Jan 2019: Nature just published an article about Rxivist and our data.
- 13 Jan 2019: The Rxivist preprint is live!