Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 64,929 bioRxiv papers from 287,755 authors.
Comparative genetic architectures of schizophrenia in East Asian and European populations
Alicia R Martin,
Brielin C Brown,
Psychiatric Genomics Consortium - Schizophrenia Working Group,
Indonesia Schizophrenia Consortium,
Genetic REsearch on schizophreniA neTwork-China and Netherland (GREAT-CN),
Wei J. Chen,
Stephen J. Glatt,
Steven E. Hyman,
Benjamin M Neale,
Patrick F Sullivan,
Mark J. Daly,
Kyung S. Hong,
Sibylle G Schwab,
René S. Kahn,
Posted 17 Oct 2018
bioRxiv DOI: 10.1101/445874
Posted 17 Oct 2018
Schizophrenia is a severe psychiatric disorder with a lifetime risk of about 1% world-wide. Most large schizophrenia genetic studies have studied people of primarily European ancestry, potentially missing important biological insights. Here we present a study of East Asian participants (22,778 schizophrenia cases and 35,362 controls), identifying 21 genome-wide significant schizophrenia associations in 19 genetic loci. Over the genome, the common genetic variants that confer risk for schizophrenia have highly similar effects in those of East Asian and European ancestry (rg=0.98), indicating for the first time that the genetic basis of schizophrenia and its biology are broadly shared across these world populations. A fixed-effect meta-analysis including individuals from East Asian and European ancestries revealed 208 genome-wide significant schizophrenia associations in 176 genetic loci (53 novel). Trans-ancestry fine-mapping more precisely isolated schizophrenia causal alleles in 70% of these loci. Despite consistent genetic effects across populations, polygenic risk models trained in one population have reduced performance in the other, highlighting the importance of including all major ancestral groups with sufficient sample size to ensure the findings have maximum relevance for all populations.
- Downloaded 1,415 times
- Download rankings, all-time:
- Site-wide: 4,178 out of 64,929
- In genetics: 358 out of 3,683
- Year to date:
- Site-wide: 2,816 out of 64,929
- Since beginning of last month:
- Site-wide: 2,469 out of 64,929
Downloads over time
Distribution of downloads per paper, site-wide
- Top preprints of 2018
- Paper search
- Author leaderboards
- Overall metrics
- The API
- Email newsletter
- 21 May 2019: PLOS Biology has published a community page about Rxivist.org and its design.
- 10 May 2019: The paper analyzing the Rxivist dataset has been published at eLife.
- 1 Mar 2019: We now have summary statistics about bioRxiv downloads and submissions.
- 8 Feb 2019: Data from Altmetric is now available on the Rxivist details page for every preprint. Look for the "donut" under the download metrics.
- 30 Jan 2019: preLights has featured the Rxivist preprint and written about our findings.
- 22 Jan 2019: Nature just published an article about Rxivist and our data.
- 13 Jan 2019: The Rxivist preprint is live!