Rxivist logo

Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 62,198 bioRxiv papers from 276,129 authors.

Ultra-fast cellular contractions in the epithelium of T. adhaerens and the "active cohesion" hypothesis

By Shahaf Armon, Matthew Storm Bull, Andres Aranda-Diaz, Manu Prakash

Posted 16 Feb 2018
bioRxiv DOI: 10.1101/258103

By definition of multi-cellularity, all animals need to keep their cells attached and intact, despite internal and external forces. Cohesion between epithelial cells provides this key feature. In order to better understand fundamental limits of this cohesion, we study the epithelium mechanics of an ultra-thin (~25 um) primitive marine animal Trichoplax adhaerens, composed essentially of two flat epithelial layers. With no known extra-cellular-matrix and no nerves or muscles, T. adhaerens was claimed the "simplest known living animal", yet is still capable of coordinated locomotion and behavior. Here we report the discovery of the fastest epithelial cellular contractions to date to be found in T. adhaerens dorsal epithelium (50% shrinkage of apical cell area within one second, at least an order of magnitude faster than known examples). Live imaging reveals emergent contractile patterns that are mostly sporadic single-cell events, but also include propagating contraction waves across the tissue. We show that cell contraction speed can be explained by current models of non-muscle actin-myosin bundles without load, while the tissue architecture and unique mechanical properties are softening the tissue, minimizing the load on a contracting cell. We propose a hypothesis, in which the physiological role of the contraction dynamics is to avoid tissue rupture ("active cohesion"), a novel concept that can be further applied to engineering of active materials.

Download data

  • Downloaded 1,269 times
  • Download rankings, all-time:
    • Site-wide: 4,691 out of 62,198
    • In biophysics: 122 out of 2,647
  • Year to date:
    • Site-wide: 13,798 out of 62,198
  • Since beginning of last month:
    • Site-wide: 12,266 out of 62,198

Altmetric data


Downloads over time

Distribution of downloads per paper, site-wide


Sign up for the Rxivist weekly newsletter! (Click here for more details.)


News