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GBAT: a gene-based association method for robust trans-gene regulation detection

By Xuanyao Liu, Joel A Mefford, Andrew Dahl, Meena Subramaniam, Alexis Battle, Alkes L. Price, Noah Zaitlen

Posted 20 Aug 2018
bioRxiv DOI: 10.1101/395970

Identification of trans-eQTLs has been limited by a heavy multiple testing burden, read-mapping biases, and hidden confounders. To address these issues, we developed GBAT, a powerful gene-based method that allows robust detection of trans gene regulation. Using simulated and real data, we show that GBAT drastically increases detection of trans-gene regulation over standard trans-eQTL analyses.

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