Rxivist logo

Negative Feedback Facilitates Temperature Robustness in Biomolecular Circuit Dynamics

By Shaunak Sen, Richard M. Murray

Posted 22 Jul 2014
bioRxiv DOI: 10.1101/007385

Temporal dynamics in many biomolecular circuits can change with temperature because of the temperature dependence of underlying reaction rate parameters. It is generally unclear what circuit mechanisms can inherently facilitate robustness in the dynamics to variations in temperature. Here, we address this issue using a combination of mathematical models and experimental measurements in a cell-free transcription-translation system. We find that negative transcriptional feedback can reduce the effect of temperature variation on circuit dynamics. Further, we find that effective negative feedback due to first-order degradation mechanisms can also enable such a temperature robustness effect. Finally, we estimate temperature dependence of key parameters mediating such negative feedback mechanisms. These results should be useful in the design of temperature robust circuit dynamics.

Download data

  • Downloaded 448 times
  • Download rankings, all-time:
    • Site-wide: 55,646
    • In systems biology: 1,354
  • Year to date:
    • Site-wide: 107,242
  • Since beginning of last month:
    • Site-wide: 107,242

Altmetric data

Downloads over time

Distribution of downloads per paper, site-wide


Sign up for the Rxivist weekly newsletter! (Click here for more details.)