Epigenetic modification of chromatin plays a pivotal role in regulating gene expression during cell differentiation. The scale and complexity of epigenetic data pose a significant challenge for biologists to identify the regulatory events controlling each stage of cell differentiation. Here, we present a new method, called Snapshot, that uses epigenetic data to generate a hierarchical visualization for the DNA regions segregating with respect to epigenetics along any given cell differentiation hierarchy of interest. Different cell type hierarchies may be used to highlight the epigenetic history specific to any particular lineage of cell differentiation. We demonstrate the utility of Snapshot using data from the VISION project, an international project for ValIdated Systematic IntegratiON of epigenomic data in mouse and human hematopoiesis.
- Downloaded 669 times
- Download rankings, all-time:
- Site-wide: 25,647 out of 103,764
- In bioinformatics: 3,510 out of 9,474
- Year to date:
- Site-wide: 52,178 out of 103,764
- Since beginning of last month:
- Site-wide: 47,008 out of 103,764
Downloads over time
Distribution of downloads per paper, site-wide
- 18 Dec 2019: We're pleased to announce PanLingua, a new tool that enables you to search for machine-translated bioRxiv preprints using more than 100 different languages.
- 21 May 2019: PLOS Biology has published a community page about Rxivist.org and its design.
- 10 May 2019: The paper analyzing the Rxivist dataset has been published at eLife.
- 1 Mar 2019: We now have summary statistics about bioRxiv downloads and submissions.
- 8 Feb 2019: Data from Altmetric is now available on the Rxivist details page for every preprint. Look for the "donut" under the download metrics.
- 30 Jan 2019: preLights has featured the Rxivist preprint and written about our findings.
- 22 Jan 2019: Nature just published an article about Rxivist and our data.
- 13 Jan 2019: The Rxivist preprint is live!