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Snapshot: clustering and visualizing epigenetic history during cell differentiation

By Guanjue Xiang, Belinda Giardine, Lin An, Chen Sun, Cheryl A. Keller, Elisabeth F. Heuston, David Bodine, Ross C Hardison, Yu Zhang

Posted 09 Apr 2018
bioRxiv DOI: 10.1101/291880

Epigenetic modification of chromatin plays a pivotal role in regulating gene expression during cell differentiation. The scale and complexity of epigenetic data pose a significant challenge for biologists to identify the regulatory events controlling each stage of cell differentiation. Here, we present a new method, called Snapshot, that uses epigenetic data to generate a hierarchical visualization for the DNA regions segregating with respect to epigenetics along any given cell differentiation hierarchy of interest. Different cell type hierarchies may be used to highlight the epigenetic history specific to any particular lineage of cell differentiation. We demonstrate the utility of Snapshot using data from the VISION project, an international project for ValIdated Systematic IntegratiON of epigenomic data in mouse and human hematopoiesis.

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