Rxivist logo

Human-specific changes in two functional enhancers of FOXP2

By Antonio Benítez-Burraco, Raúl Torres-Ruiz, Pere Gelabert Xirinachs, Carles Lalueza-Fox, Sandra Rodríguez-Perales, Paloma García-Bellido

Posted 28 Jun 2017
bioRxiv DOI: 10.1101/157016

Two functional enhancers of FOXP2, a gene important for language development and evolution, exhibit several human-specific changes compared to extinct hominins that are located within the binding site for different transcription factors. Specifically, Neanderthals and Denisovans bear the ancestral allele in one position within the binding site for SMARCC1, involved in brain development and vitamin D metabolism. This change might have resulted in a different pattern of FOXP2 expression in our species compared to extinct hominins.

Download data

  • Downloaded 824 times
  • Download rankings, all-time:
    • Site-wide: 18,225 out of 101,137
    • In evolutionary biology: 1,077 out of 6,033
  • Year to date:
    • Site-wide: 75,761 out of 101,137
  • Since beginning of last month:
    • Site-wide: 69,844 out of 101,137

Altmetric data


Downloads over time

Distribution of downloads per paper, site-wide


PanLingua

Sign up for the Rxivist weekly newsletter! (Click here for more details.)


News

  • 20 Oct 2020: Support for sorting preprints using Twitter activity has been removed, at least temporarily, until a new source of social media activity data becomes available.
  • 18 Dec 2019: We're pleased to announce PanLingua, a new tool that enables you to search for machine-translated bioRxiv preprints using more than 100 different languages.
  • 21 May 2019: PLOS Biology has published a community page about Rxivist.org and its design.
  • 10 May 2019: The paper analyzing the Rxivist dataset has been published at eLife.
  • 1 Mar 2019: We now have summary statistics about bioRxiv downloads and submissions.
  • 8 Feb 2019: Data from Altmetric is now available on the Rxivist details page for every preprint. Look for the "donut" under the download metrics.
  • 30 Jan 2019: preLights has featured the Rxivist preprint and written about our findings.
  • 22 Jan 2019: Nature just published an article about Rxivist and our data.
  • 13 Jan 2019: The Rxivist preprint is live!